维甲酸X受体α通过与过氧化物酶体增殖物激活受体形成异二聚体复合物来反式激活乙型肝炎病毒增强子1元件。
Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
作者信息
Huan B, Kosovsky M J, Siddiqui A
机构信息
Department of Microbiology, University of Colorado Medical School, Denver 80262.
出版信息
J Virol. 1995 Jan;69(1):547-51. doi: 10.1128/JVI.69.1.547-551.1995.
Abstract
The hepatitis B virus enhancer 1 contains a retinoic acid responsive element (RARE). We have previously demonstrated that retinoid X receptor alpha (RXR alpha) transactivates enhancer 1 by binding to the RARE. The present study has revealed that a heterodimeric complex composed of RXR alpha and peroxisome proliferator-activated receptor (PPAR) interacts with the hepatitis B virus RARE. Transient transfection studies, in conjunction with in vitro DNA binding data, support the hypothesis that the RXR alpha-PPAR heterodimer transactivates enhancer 1.
摘要
乙肝病毒增强子1含有一个视黄酸反应元件（RARE）。我们之前已经证明，视黄酸X受体α（RXRα）通过与RARE结合来反式激活增强子1。本研究揭示，由RXRα和过氧化物酶体增殖物激活受体（PPAR）组成的异源二聚体复合物与乙肝病毒RARE相互作用。瞬时转染研究结合体外DNA结合数据，支持RXRα-PPAR异源二聚体反式激活增强子1这一假说。
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.维甲酸X受体α通过与过氧化物酶体增殖物激活受体形成异二聚体复合物来反式激活乙型肝炎病毒增强子1元件。
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本文引用的文献
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RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.RFX1与增强子因子C相同，并作为乙肝病毒增强子的反式激活因子发挥作用。
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.核因子EF-C、肝细胞核因子4（HNF-4）及视黄酸X受体α（RXRα）与乙型肝炎病毒增强子I的功能相互作用
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