Seino Y, Yamada Y
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine.
Nihon Rinsho. 1994 Oct;52(10):2686-92.
Impaired insulin secretion and/or insulin resistance are the primary defect(s) in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). Both seem to be regulated by the genetic factors in addition to environmental factors. Recent Advances are revealing the molecular mechanism how insulin is secreted in response to glucose and how insulin acts on the target tissues. Several genes including glucokinase and mitochondria have been shown to be responsible for the development of NIDDM, but NIDDM is the polygenic disease and most of NIDDM patients may have still-uncharacterized diabetogenic factors.
胰岛素分泌受损和/或胰岛素抵抗是非胰岛素依赖型糖尿病（NIDDM）发病机制中的主要缺陷。除环境因素外，两者似乎都受遗传因素调控。最近的进展揭示了胰岛素如何响应葡萄糖分泌以及如何作用于靶组织的分子机制。包括葡萄糖激酶和线粒体在内的几个基因已被证明与NIDDM的发生有关，但NIDDM是一种多基因疾病，大多数NIDDM患者可能仍有未被鉴定的致糖尿病因素。
