Seino S
Division of Molecular Medicine, Chiba University School of Medicine, Chiba.
Intern Med. 1996 May;35(5):347-55. doi: 10.2169/internalmedicine.35.347.
Non-insulin-dependent diabetes mellitus (NIDDM) is one of the most common metabolic and endocrine disorders in developed countries. NIDDM is a multifactorial disorder in which genetic factors play a complex role in its development. Until recently, little has been known of the genetic determinants of NIDDM. Advances in molecular biological and molecular genetic approaches have now made it possible to begin to identify the diabetes susceptibility genes in NIDDM. This review describes the progress of recent research in the molecular genetic aspects of NIDDM.
非胰岛素依赖型糖尿病（NIDDM）是发达国家最常见的代谢和内分泌疾病之一。NIDDM是一种多因素疾病，其中遗传因素在其发病过程中起着复杂的作用。直到最近，人们对NIDDM的遗传决定因素知之甚少。分子生物学和分子遗传学方法的进展现在使得开始识别NIDDM中的糖尿病易感基因成为可能。这篇综述描述了NIDDM分子遗传学方面近期研究的进展。
