Kornegay J N, Sharp N J, Schueler R O, Betts C W
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Lab Anim Sci. 1994 Aug;44(4):331-3.
Golden retriever muscular dystrophy (GRMD) is an X-linked myopathy homologous with Duchenne muscular dystrophy of human beings. Affected dogs have progressive clinical dysfunction due to muscle wasting and contractures. Deficits progress particularly rapidly between 3 and 6 months of age. To better characterize the role of contractures in this deterioration, the flexor surface, nonweight-bearing tarsal joint angle was measured in GRMD-affected dogs and clinically normal littermates at both ages. The mean +/- SD tarsal joint angle for clinically normal dogs decreased from 164.6 +/- 6.09 degrees to 145.6 +/- 8.80 degrees between 3 and 6 months (P < 0.0005). The value for GRMD-affected dogs decreased from 153.3 +/- 11.44 degrees to 117.6 +/- 24.55 degrees (P < 0.005). The angle for clinically normal dogs was greater than that for GRMD-affected dogs at both ages (P < 0.05 at 3 months and P < 0.01 at 6 months). The decrease in tarsal joint angle, at times to less than 90 degrees, correlated well with other phenotypic features of GRMD, such as loss of the ability to walk.
金毛寻回犬肌营养不良症（GRMD）是一种与人类杜氏肌营养不良症同源的X连锁肌病。患病犬因肌肉萎缩和挛缩而出现进行性临床功能障碍。在3至6月龄期间，功能缺陷进展尤为迅速。为了更好地描述挛缩在这种病情恶化中的作用，对患GRMD的犬及其临床正常的同窝仔犬在这两个年龄段的屈侧非负重跗关节角度进行了测量。临床正常犬的平均跗关节角度（±标准差）在3至6月龄期间从164.6±6.09度降至145.6±8.80度（P<0.0005）。患GRMD犬的该值从153.3±11.44度降至117.6±24.55度（P<0.005）。在两个年龄段，临床正常犬的角度均大于患GRMD犬的角度（3月龄时P<0.05，6月龄时P<0.01）。跗关节角度的减小，有时会小于90度，与GRMD的其他表型特征，如行走能力丧失，密切相关。
