School of Veterinary Medicine and Animal Science, Department of Surgery, University of São Paulo, São Paulo, Brazil.
Res Vet Sci. 2011 Oct;91(2):188-93. doi: 10.1016/j.rvsc.2011.01.007. Epub 2011 Feb 18.
Dogs suffering from Golden Retriever muscular dystrophy (GRMD) present symptoms that are similar to human patients with Duchenne muscular dystrophy (DMD). Phenotypic variability is common in both cases and correlates with disease progression and response to therapy. Physical therapy assessment tools were used to study disease progression and assess phenotypic variability in dogs with GRMD. At 5 (T0), 9 (T1), 13 (T2) and 17 (T3)months of age, the physical features, joint ranges of motion (ROM), limb and thorax circumferences, weight and creatine kinase (CK) levels were assessed in 11 dogs with GRMD. Alterations of physical features were higher at 13 months, and different disease progression rates were observed. Passive ROM decreased until 1 year old, which was followed by a decline of elbow and tarsal ROM. Limb and thorax circumferences, which were corrected for body weight, decreased significantly between T0 and T3. These measurements can be used to evaluate disease progression in dogs with GRMD and to help discover new therapies for DMD patients.
患有金毛猎犬肌肉营养不良症（GRMD）的狗表现出的症状与人类杜氏肌营养不良症（DMD）患者相似。在这两种情况下，表型变异性都很常见，与疾病进展和对治疗的反应相关。物理治疗评估工具被用于研究 GRMD 犬的疾病进展并评估表型变异性。在 5 个月（T0）、9 个月（T1）、13 个月（T2）和 17 个月（T3）时，对 11 只 GRMD 犬的身体特征、关节活动范围（ROM）、四肢和胸部周长、体重和肌酸激酶（CK）水平进行了评估。在 13 个月时，身体特征的变化更高，并且观察到不同的疾病进展速度。被动 ROM 直到 1 岁时才下降，随后肘部和跗关节 ROM 下降。经体重校正的四肢和胸部周长在 T0 至 T3 期间显著下降。这些测量值可用于评估 GRMD 犬的疾病进展，并有助于为 DMD 患者发现新的治疗方法。
