Winkler W B, Karnik R, Slany J
Department of Internal Medicine II, Krankenanstalt Rudolfstiftung, Wien, Austria.
Lancet. 1994 Dec 3;344(8936):1541-2. doi: 10.1016/s0140-6736(94)90352-2.
Three male patients with purulent pericarditis, in whom complete drainage could not be obtained by pericardiocentesis, were treated with transcatheter intrapericardial urokinase to prevent the development of chronic constrictive pericarditis. As shown by echocardiography, the intrapericardial fibrin layers disappeared in two cases and were reduced by more than half in the third. Effects on systemic coagulation indices and complications related to intrapericardial lysis were not observed.
三名患有脓性心包炎的男性患者，通过心包穿刺术无法实现完全引流，遂接受经导管心包内注射尿激酶治疗，以预防慢性缩窄性心包炎的发生。超声心动图显示，两例患者的心包内纤维蛋白层消失，第三例患者的心包内纤维蛋白层减少了一半以上。未观察到对全身凝血指标的影响以及与心包内溶栓相关的并发症。
