Johansson-Wallsten C E, Meyerson B J
Department of Medical Pharmacology, Uppsala University, Sweden.
Neuropharmacology. 1994 Mar-Apr;33(3-4):325-30. doi: 10.1016/0028-3908(94)90061-2.
The 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) induces hypothermia and a flat body posture in rats. Tolerance to 8-OH-DPAT develops in adult rats with regard to these responses. The ontogeny of the ability to induce tolerance to the hypothermia and the flat body posture elicited by 8-OH-DPAT was studied. Rat pups of both sexes were given 8-OH-DPAT, 100 micrograms/kg (0.352 mumol/kg) or saline for 1, 4 or 12 days between 22 and 34 days of age. At 26 days of age no attenuation was induced by treatment during the previous 4 days. In contrast, at 34 days of age there was a clear attenuation of both responses induced by 8-OH-DPAT after an analogous 4 day treatment. The data indicate that the ability to induce tolerance to 8-OH-DPAT is not developed before 26 days of age in the rat.
5-羟色胺1A受体激动剂8-羟基-2-(二正丙基氨基)四氢萘(8-OH-DPAT)可使大鼠体温降低并呈平卧式体态。成年大鼠对8-OH-DPAT的这些反应会产生耐受性。研究了诱导对8-OH-DPAT引起的体温降低和平卧式体态产生耐受性的能力的个体发生情况。在22至34日龄之间，给两性幼鼠注射100微克/千克(0.352微摩尔/千克)的8-OH-DPAT或生理盐水，持续1、4或12天。在26日龄时，前4天的处理未引起反应减弱。相反，在34日龄时，经过类似的4天处理后，8-OH-DPAT诱导的两种反应均明显减弱。数据表明，大鼠在26日龄之前未发育出对8-OH-DPAT产生耐受性的能力。
