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新型东方医学处方TJS - 010增强大鼠中8 - OH - DPAT诱导的效应。

TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats.

作者信息

Kagaya A, Tanra A J, Shinno H, Kugaya A, Muraoka M, Oyamada T, Uchitomi Y, Yamawaki S

机构信息

Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.

出版信息

J Neural Transm (Vienna). 1996;103(1-2):69-75. doi: 10.1007/BF01292617.

DOI:10.1007/BF01292617
PMID:9026378
Abstract

We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.

摘要

我们评估了一种新型东方医学处方TJS - 010对由（±）-8 - 羟基 - 2 -（二 - N - 丙基氨基）- 四氢萘（8 - OH - DPAT）激活血清素（5 - HT）-1A受体所诱导的大鼠体温过低和平躺体位的影响。8 - OH - DPAT以剂量和时间依赖性方式诱导体温过低。0.1mg/kg的8 - OH - DPAT所诱导的体温过低在给予500和750mg/kg的TJS - 010后增强。在0.1mg/kg的浓度下，8 - OH - DPAT还使大鼠出现平躺体位，而750mg/kg的TJS - 010增加了平躺体位。这些结果表明TJS - 010可促进中枢神经系统中的5 - HT - 1A受体。

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