González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez F J, Díaz-Cano S
Department of Pathology, Virgen Macarena University Hospital, School of Medicine, Seville, Spain.
Pathol Res Pract. 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4.
Blue nevus is an uncommon pigmented lesion of dermal melanocytes. By convention, two well defined histologic variants, designated as "common" and "cellular", have been recognised. In the last few years, these lesions have attracted much attention due to the recognition of news entities and to its confusion with malignant melanoma. In the present review, we point out the more striking features of new related entities (combined nevus, deep penetrating nevus, compound blue nevus) and establish the differential diagnosis with conflictive lesions such as atypical blue nevus, locally aggressive blue nevus, congenital giant melanocytic nevus with nodular growth and melanocytic dermal tumor of unpredictable outcome. We also review the concept of malignant blue nevus and the significance of lymph node metastases. The blue nevus is an uncommon pigmented lesion consisting of dermal melanocytes that can appear in diverse forms: dendritic, spindle-shaped, oval-shaped, or polyhedral. Although it usually occurs in skin, it has been reported in other locations, such as oral mucosa, sclera, uterine cervix, vagina, prostate, spermatic cord, pulmonary hilus, orbit, conjunctiva, maxillary sinus, breast, and lymph nodes 3,8,42,49. Generally, it occurs in adults as a single, acquired, intensely pigmented lesion, although familial and multiple nevi have been reported 7,39. By convention, there are two well-defined histologic variants, designated as "common" and "cellular", but lesions often manifest intermediate features. In the last few years, blue nevus has attracted much attention due to the recognition of new (clinical and histologic) entities and to its confusion with malignant melanoma.(ABSTRACT TRUNCATED AT 250 WORDS)
蓝痣是一种罕见的真皮黑素细胞色素沉着性病变。按照惯例，已识别出两种明确的组织学变体，即“普通型”和“细胞型”。在过去几年中，由于新实体的发现以及与恶性黑色素瘤的混淆，这些病变引起了广泛关注。在本综述中，我们指出了新相关实体（复合痣、深部穿透性痣、复合蓝痣）的更显著特征，并与诸如非典型蓝痣、局部侵袭性蓝痣、具有结节性生长的先天性巨大黑素细胞痣以及预后不可预测的黑素细胞真皮肿瘤等有争议的病变进行鉴别诊断。我们还回顾了恶性蓝痣的概念以及淋巴结转移的意义。蓝痣是一种罕见的色素沉着性病变，由真皮黑素细胞组成，可呈现多种形态：树突状、梭形、椭圆形或多面体形。虽然它通常发生在皮肤，但也有在其他部位的报道，如口腔黏膜、巩膜、子宫颈、阴道、前列腺、精索、肺门、眼眶、结膜、上颌窦、乳房和淋巴结[3,8,42,49]。一般来说，它在成年人中表现为单个后天性的深色病变，不过也有家族性和多发性痣的报道[7,39]。按照惯例，有两种明确的组织学变体，即“普通型”和“细胞型”，但病变常表现出中间特征。在过去几年中，由于新（临床和组织学）实体的发现以及与恶性黑色素瘤的混淆，蓝痣引起了广泛关注。（摘要截断于250字）
