长期接受血液透析患者的核抗原抗体
Antibodies to nuclear antigens in patients undergoing long-term hemodialysis.
作者信息
Nolph K D, Husted F C, Sharp G C, Siemsen A W
出版信息
Am J Med. 1976 May 10;60(5):673-6. doi: 10.1016/0002-9343(76)90502-7.
Free nuclei of damaged leukocytes adhere to hemodialysis membranes. To see if the incidence of antibodies to nuclear antigens is increased in patients receiving hemodialysis, serums from 77 patients undergoing long-term dialysis for one to 66 months were assayed for antibodies to extractable nuclear antigen and native deoxyribonucleic acid (DNA) by hemagglutination technics. Serums from 300 other hospital patients (who did not have diseases known to be associated with antibodies to nuclear antigens) were assayed concurrently. Of the 77 dialysis patients, serums from 19 (25 per cent) were positive for one or both antibodies. Serums from only three (1 per cent) of the 300 other patients had detectable antibodies. The incidence was significantly higher (p less than 0.001) in dialysis patients suggesting the possibility of sensitization to nuclear antigens during hemodialysis.
受损白细胞的游离细胞核会黏附于血液透析膜上。为了探究接受血液透析的患者中核抗原抗体的发生率是否增加，采用血凝技术对77例接受长期透析1至66个月患者的血清进行了可提取核抗原和天然脱氧核糖核酸（DNA）抗体检测。同时对300名其他医院患者（他们没有已知与核抗原抗体相关的疾病）的血清进行了检测。在77例透析患者中，19例（25%）患者的血清一种或两种抗体呈阳性。300名其他患者中只有3例（1%）的血清检测到抗体。透析患者中的发生率显著更高（p小于0.001），提示血液透析期间可能对核抗原致敏。
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