Olesen B, Kolmos H J, Orskov F, Orskov I
International Escherichia and Klebsiella Centre (WHO), Statens Seruminstitut, Copenhagen, Denmark.
Scand J Infect Dis. 1994;26(4):406-10. doi: 10.3109/00365549409008613.
A multiresistant, lactose-negative Escherichia coli O78:H10 was isolated from 19 patients in Greater Copenhagen over a period of 8 months. At least 14 cases were community-acquired. 18 isolates originated from urine cultures and 1 from a faecal sample. 13 patients were predisposed to urinary tract infection (UTI) and 11 patients showed clinical signs of UTI. This is the first report of E. coli O78:H10 causing human disease. The cluster was probably food-borne, but the source was not identified. This cluster of identical disease associated E. coli was only uncovered because of its multiresistance and lactose-negative phenotype.
在8个月的时间里，从哥本哈根大区的19名患者中分离出一株多重耐药、乳糖阴性的大肠杆菌O78:H10。至少14例为社区获得性感染。18株分离菌来自尿液培养物，1株来自粪便样本。13名患者易患尿路感染（UTI），11名患者表现出UTI的临床症状。这是关于大肠杆菌O78:H10引起人类疾病的首例报告。该菌簇可能通过食物传播，但源头尚未确定。这一与疾病相关的相同大肠杆菌菌簇只是因其多重耐药和乳糖阴性表型才被发现。
