Granström G, Granström M
Department of Infectious Diseases, Danderyd Hospital, Sweden.
Scand J Infect Dis. 1994;26(4):453-7. doi: 10.3109/00365549409008619.
The effect of erythromycin treatment on antibody responses to Bordetella pertussis filamentous haemagglutinin (FHA) and pertussis toxin (PT) was investigated in convalescent blood samples from 105 children with pertussis. Erythromycin had been given to 59 children, median age 3.2 years (range 0.3-9.9) on median day 7 (range 11-14) after onset of disease while the remaining 46 children, age 3.45 (0.6-8.1) were untreated. No significant differences in IgG antibody concentration were noted to FHA by ELISA and to PT, neither by NT nor by ELISA, but a tendency towards lower median titers was seen to both antigens and by both type of assays in the erythromycin-treated group. Similarly, early erythromycin treatment i.e. within 7 days of onset of symptoms, did not influence significantly of the development of the antibody responses but tended to lead to lower titer levels. A significant response to PT and FHA was found in about 90% of blood samples, irrespective of treatment. All 56 children with culture-confirmed B. pertussis infection had a significant response to PT. The study has thus shown a slight but not significant effect of erythromycin treatment on antibody responses in pertussis.
在105名百日咳患儿恢复期的血样中，研究了红霉素治疗对百日咳博德特氏菌丝状血凝素（FHA）和百日咳毒素（PT）抗体反应的影响。59名儿童接受了红霉素治疗，疾病发作后中位第7天（范围11 - 14天）时的中位年龄为3.2岁（范围0.3 - 9.9岁），其余46名儿童，年龄3.45岁（0.6 - 8.1岁）未接受治疗。通过ELISA检测，针对FHA的IgG抗体浓度，以及通过NT和ELISA检测针对PT的IgG抗体浓度，均未发现显著差异，但在红霉素治疗组中，两种抗原通过两种检测方法测得的中位滴度均有降低趋势。同样，早期红霉素治疗，即症状出现7天内进行治疗，对抗体反应的发展没有显著影响，但往往导致滴度水平较低。无论是否接受治疗，约90%的血样对PT和FHA有显著反应。所有56名经培养确诊为百日咳博德特氏菌感染的儿童对PT均有显著反应。因此，该研究表明红霉素治疗对百日咳抗体反应有轻微但不显著的影响。
