Suptel' E A, Zagornaia N B, Bass T M
Antibiotiki. 1976 Nov;21(11):996-9.
The effect of some chemotherapeutics on intercellular growth of Sh. sonnei and their capacity for penetration into cells Hep-2 and primarily triptinized cells of the monkey kidneys was studied. By the character of their effect the drugs were divided into 3 groups. The drugs of the first group, i.e. furazolidone had no effect on intracellular growth of Shigella. The drugs of the second group, i.e. neomycin, monomycin, kanamycin, polymyxin M, ampicillin, negram and 5-NOK induced a rapid decrease in the number of the specimens located inside the cells. The drugs of the third group, i. e. enteroseptol, streptomycin and tetracycline promoted a decrease in the intracellular growth of Shigella by the 3rd-4th day. None of the drugs could be detected inside the cells in the concentrations corresponding to the minimal bacteriostatic ones with respect to Shigella. The activity of the drugs of the second group was connected with their cytotoxicity.
研究了某些化疗药物对宋内志贺菌细胞间生长的影响及其穿透Hep - 2细胞和猴肾原代胰蛋白酶处理细胞的能力。根据其作用特点，将这些药物分为3组。第一组药物，即呋喃唑酮，对志贺菌的细胞内生长没有影响。第二组药物，即新霉素、单霉素、卡那霉素、多粘菌素M、氨苄青霉素、奈替米星和5 - NOK，使位于细胞内的标本数量迅速减少。第三组药物，即琥乙红霉素、链霉素和四环素，在第3 - 4天促进了志贺菌细胞内生长的减少。在对应于对志贺菌最小抑菌浓度的浓度下，细胞内均未检测到任何一种药物。第二组药物的活性与其细胞毒性有关。
