Chaloupka J C, Viñuela F, Sakai N, Vinters H V, Robert J, Duckwiler G R
Department of Radiology, Yale University School of Medicine, New Haven, CT 06510.
AJNR Am J Neuroradiol. 1994 Sep;15(8):1529-36.
To determine whether microvascular damage occurs from superselective intraarterial injection of amobarbital sodium using the swine endovascular embolization model.
Thirty-four swine underwent percutaneous femoral puncture for superselective catheterization of the proximal artery of the rete. Varying concentrations of amobarbital sodium were prepared (12.5 to 100 mg/mL solution) in either normal saline or sterile water (105 mOsm/L to 1138 mOsm/L) of which one concentration was infused slowly into one ipsilateral rete. Control infusions were also performed. Histopathologic changes were evaluated at 30 minutes and 10 days after infusion, using standard light and electron microscopy techniques.
Moderate vasospasm occurred only in three swine at 100 mg/mL amobarbital sodium in normal saline. Light microscopy showed no significant histologic changes in the retia at any of the tested concentrations of amobarbital sodium. Electron microscopy showed ultrastructural alterations in the intima only at the higher amobarbital sodium concentrations.
Concerns for inducing significant damage to cerebral microvasculature by superselective injection of amobarbital sodium at the usually recommended concentrations and doses are probably not justified.
利用猪血管内栓塞模型确定超选择性动脉内注射异戊巴比妥钠是否会导致微血管损伤。
34头猪经皮股动脉穿刺，对网状动脉近端进行超选择性插管。在生理盐水或无菌水中制备不同浓度的异戊巴比妥钠（12.5至100mg/mL溶液）（渗透压为105mOsm/L至1138mOsm/L），将其中一种浓度缓慢注入一侧网状动脉。同时进行对照输注。在输注后30分钟和10天，使用标准光学和电子显微镜技术评估组织病理学变化。
仅3头猪在生理盐水配制的100mg/mL异戊巴比妥钠注射后出现中度血管痉挛。光学显微镜检查显示，在任何测试浓度的异戊巴比妥钠下，网状动脉均未出现明显的组织学变化。电子显微镜检查显示，仅在较高浓度的异戊巴比妥钠下，内膜出现超微结构改变。
通常推荐的浓度和剂量下，超选择性注射异戊巴比妥钠会对脑微血管造成显著损伤的担忧可能没有依据。
