血浆置换与后续脉冲环磷酰胺同步治疗后重度系统性红斑狼疮的无治疗缓解
Treatment-free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide.
作者信息
Euler H H, Schroeder J O, Harten P, Zeuner R A, Gutschmidt H J
机构信息
Christian Albrecht University, Kiel, Germany.
出版信息
Arthritis Rheum. 1994 Dec;37(12):1784-94. doi: 10.1002/art.1780371212.
OBJECTIVE
To investigate the effect of an intensified treatment protocol synchronizing plasmapheresis with subsequent pulse cyclophosphamide for severe systemic lupus erythematosus (SLE).
METHODS
A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high-dose pulse cyclophosphamide (36 mg/kg) followed by 6 months of peroral immunosuppression was used to treat 14 patients with severe SLE.
RESULTS
Rapid improvement was achieved in all patients. Immunosuppressants, including corticosteroids, were withdrawn at month 6 in 12 patients. Eight patients continued without treatment for a mean observation period of 5.6 years (46-91 months).
CONCLUSION
The results demonstrate that treatment-free clinical remission can be achieved in some patients with severe SLE.
目的
探讨强化治疗方案（同步进行血浆置换及后续脉冲环磷酰胺治疗）对重症系统性红斑狼疮（SLE）的疗效。
方法
采用血浆置换方案（3×60 ml/kg）及后续大剂量脉冲环磷酰胺（36 mg/kg），随后进行6个月口服免疫抑制治疗，以治疗14例重症SLE患者。
结果
所有患者均迅速改善。12例患者在第6个月停用了包括皮质类固醇在内的免疫抑制剂。8例患者持续未接受治疗，平均观察期为5.6年（46 - 91个月）。
结论
结果表明，部分重症SLE患者可实现无需治疗的临床缓解。
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