Euler H H, Schroeder J O, Harten P, Zeuner R A, Gutschmidt H J
Christian Albrecht University, Kiel, Germany.
Arthritis Rheum. 1994 Dec;37(12):1784-94. doi: 10.1002/art.1780371212.
To investigate the effect of an intensified treatment protocol synchronizing plasmapheresis with subsequent pulse cyclophosphamide for severe systemic lupus erythematosus (SLE).
A protocol of plasmapheresis (3 x 60 ml/kg) and subsequent high-dose pulse cyclophosphamide (36 mg/kg) followed by 6 months of peroral immunosuppression was used to treat 14 patients with severe SLE.
Rapid improvement was achieved in all patients. Immunosuppressants, including corticosteroids, were withdrawn at month 6 in 12 patients. Eight patients continued without treatment for a mean observation period of 5.6 years (46-91 months).
The results demonstrate that treatment-free clinical remission can be achieved in some patients with severe SLE.
探讨强化治疗方案（同步进行血浆置换及后续脉冲环磷酰胺治疗）对重症系统性红斑狼疮（SLE）的疗效。
采用血浆置换方案（3×60 ml/kg）及后续大剂量脉冲环磷酰胺（36 mg/kg），随后进行6个月口服免疫抑制治疗，以治疗14例重症SLE患者。
所有患者均迅速改善。12例患者在第6个月停用了包括皮质类固醇在内的免疫抑制剂。8例患者持续未接受治疗，平均观察期为5.6年（46 - 91个月）。
结果表明，部分重症SLE患者可实现无需治疗的临床缓解。
