Teske S, Ohlrich S J, Gole G, Spiro P, Miller M, Sullivan T J
Department of Ophthalmology, Royal Childrens Hospital, Brisbane, Queensland.
Aust N Z J Ophthalmol. 1994 Feb;22(1):13-7. doi: 10.1111/j.1442-9071.1994.tb01689.x.
Capillary haemangiomas are vascular tumours of childhood characterised by proliferative and involutional phases and affecting 1% to 2% of newborns. Recently, recombinant interferons have been used in the treatment of life and sight threatening complications of these tumours.
The history, results of examination, investigations, management and outcome of two patients with sight-threatening orbital capillary haemangiomas treated with recombinant interferon alpha-2a and 2b respectively were reviewed.
Orbital and systemic lesions displayed good response to interferons. Side effects noted were transient pyrexia and elevated serum aminotransferase levels. Disturbed liver function test results occurred in one case and normalised with temporary cessation of therapy.
The interferons are a useful alternative treatment of orbital capillary haemangioma in selected cases.
毛细血管瘤是儿童期的血管肿瘤，具有增殖期和消退期，影响1%至2%的新生儿。最近，重组干扰素已被用于治疗这些肿瘤危及生命和视力的并发症。
回顾了分别用重组干扰素α-2a和2b治疗的两名患有危及视力的眼眶毛细血管瘤患者的病史、检查结果、调查、治疗及预后情况。
眼眶和全身病变对干扰素显示出良好反应。观察到的副作用为短暂发热和血清转氨酶水平升高。1例出现肝功能检查结果异常，暂停治疗后恢复正常。
在某些病例中，干扰素是眼眶毛细血管瘤的一种有效替代治疗方法。
