Aufrère G, Ménez J F, Beaugé F, Duffy O, Le Bourhis B
Centre de Recherche Pernod-Ricard, Créteil, France.
Alcohol Alcohol. 1994 Jul;29(4):397-401.
In rats selected for their differences in sleep time following acute administration of ethanol (high or low alcohol sensitivity: HAS or LAS), alcohol chronic tolerance and behavioural dependence were determined. Tolerance was assessed by calculating the interval between the loss and regain of the righting reflex following an acute administration of ethanol (4 g/kg body wt), after intoxication by inhalation of ethanol vapour for 3 weeks. The importance of behavioural dependence was estimated by measuring the ethanol intake in a free-choice situation water/ethanol (10% v/v), after intoxication by inhalation for 4 weeks. The two HAS and LAS lines did not show any behavioural dependence, while they developed a significant tolerance to the hypnotic effect of ethanol, which was more marked for the LAS line.
在因急性给予乙醇后睡眠时间存在差异而被挑选出的大鼠（高或低酒精敏感性：高酒精敏感性或低酒精敏感性）中，测定了酒精慢性耐受性和行为依赖性。通过计算急性给予乙醇（4克/千克体重）后翻正反射丧失和恢复之间的间隔来评估耐受性，乙醇吸入中毒3周后进行该操作。通过在水/乙醇（10%体积/体积）自由选择情况下测量乙醇摄入量来估计行为依赖性的重要性，乙醇吸入中毒4周后进行该操作。两条高酒精敏感性和低酒精敏感性品系均未表现出任何行为依赖性，然而它们对乙醇的催眠作用产生了显著耐受性，低酒精敏感性品系的这种耐受性更为明显。
