Overstreet D H, Rezvani A H, Janowsky D S
Bowles Biomedical Research Laboratory, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599.
Alcohol Alcohol. 1990;25(1):59-65.
The behavioral and hypothermic effects of ethanol were studied in the Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats, selectively bred for differences in cholinergic sensitivity. The FSL hypercholinergic rats exhibited a significantly greater degree of hypothermia than the FRL rats, or a group of weight-matched randomly bred rats. Although there were some trends for the FSL rats to appear more depressed behaviorally after receiving ethanol, there were no significant differences between the FSL and FRL rats on quantitative behavioral measures. Blood ethanol concentrations were slightly lower in the FRL rats, but there were no differences between the FSL and control rats. These findings suggest an association between cholinergic mechanisms and ethanol sensitivity with regard to body temperature effect, but a direct causal relationship cannot be established because of similar differential sensitivities of FSL and FRL rats to a range of other neurotransmitter-altering drugs on this parameter.
在弗林德斯敏感系（FSL）大鼠和弗林德斯抗性系（FRL）大鼠中研究了乙醇的行为和体温降低效应，这两种大鼠是因胆碱能敏感性差异而选择性培育的。FSL高胆碱能大鼠表现出比FRL大鼠或一组体重匹配的随机繁殖大鼠显著更高程度的体温降低。尽管有一些趋势表明FSL大鼠在接受乙醇后行为上更抑郁，但在定量行为测量方面，FSL和FRL大鼠之间没有显著差异。FRL大鼠的血液乙醇浓度略低，但FSL大鼠和对照大鼠之间没有差异。这些发现表明胆碱能机制与乙醇敏感性在体温效应方面存在关联，但由于FSL和FRL大鼠在该参数上对一系列其他改变神经递质的药物具有相似的差异敏感性，因此无法建立直接的因果关系。
