Bradley W A, Gianturco S H
Department of Medicine, University of Alabama at Birmingham.
J Intern Med Suppl. 1994;736:33-9.
The potential role of triglyceride-rich lipoproteins (TGRLP) in the pathogenesis of atherosclerosis is briefly reviewed. Structural attributes of TGRLP are related to functional cellular interactions relative to their ability to interact with macrophage receptors and produce foam cells. Unlike low-density lipoproteins (LDL), no prior modification (oxidation or acylation) is necessary with TGRLP from certain hypertriglyceridaemic subjects and certain postprandial-TGRLP before rapid, receptor-mediated lipid engorgement occurs. In addition, arguments are examined that challenge the differing views that this lipoprotein class is not important in atherogenesis.
富含甘油三酯的脂蛋白（TGRLP）在动脉粥样硬化发病机制中的潜在作用被简要综述。TGRLP的结构特性与它们与巨噬细胞受体相互作用并产生泡沫细胞的能力相关的功能性细胞相互作用有关。与低密度脂蛋白（LDL）不同，某些高甘油三酯血症患者的TGRLP和某些餐后TGRLP在快速的、受体介导的脂质充盈发生之前，无需预先修饰（氧化或酰化）。此外，还审视了一些观点，这些观点对这一脂蛋白类别在动脉粥样硬化形成中不重要的不同看法提出了挑战。
