Whang C J, Kwon Y
Department of Neurological Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
J Korean Med Sci. 1994 Apr;9(2):123-34. doi: 10.3346/jkms.1994.9.2.123.
The goal of this study was to introduce a new method inducing an experimental brain injury model using ESWL(Extracorporeal Shock Wave Lithotripsy) and to evaluate findings of localized lesions on 1H MR imaging and the response of cerebral energy metabolism using a 31P MR spectroscope to the ESWL brain injury in cats. This study also examined effects of cerebral protective drugs. 1) There were no statistically significant changes in pH at all measurement points. 2) In the trauma group, initial decrease of PCr/Pi was seen at 30 to 60 minutes with return to control levels by 2 hours after injury(P < 0.05), followed by a second decline at 4 hours which lasted until 8 hours after injury. 3) Significant recovery in PCr/Pi(P < 0.05) was observed in both the THAM and dexamethasone treated groups at all measurement points and in the mannitol treated group only temporary recovery at 30 and 60 minutes (P < 0.05). 4) High intensity signals were seen on 1H MR imaging in traumatized animals. This study demonstrated the immediate and persistent recovery of cerebral energy metabolism using THAM or dexamethasone and an immediate but transient effect with mannitol in traumatized animals.
本研究的目的是引入一种使用体外冲击波碎石术（ESWL）诱导实验性脑损伤模型的新方法，并在猫中评估1H磁共振成像上局部病变的表现以及使用31P磁共振波谱仪对ESWL脑损伤的脑能量代谢反应。本研究还检测了脑保护药物的作用。1）在所有测量点，pH值均无统计学上的显著变化。2）在创伤组中，磷酸肌酸/无机磷（PCr/Pi）在伤后30至60分钟出现初始下降，至伤后2小时恢复至对照水平（P<0.05），随后在4小时出现第二次下降并持续至伤后8小时。3）在所有测量点，三羟甲基氨基甲烷（THAM）和地塞米松治疗组的PCr/Pi均有显著恢复（P<0.05），而甘露醇治疗组仅在30和60分钟时有短暂恢复（P<0.05）。4）在受创伤动物的1H磁共振成像上可见高强度信号。本研究表明，THAM或地塞米松可使受创伤动物的脑能量代谢立即且持续恢复，而甘露醇则产生立即但短暂的效果。
