在内质网和高尔基体中的保留与检索。
Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus.
作者信息
Nilsson T, Warren G
机构信息
Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK.
出版信息
Curr Opin Cell Biol. 1994 Aug;6(4):517-21. doi: 10.1016/0955-0674(94)90070-1.
Abstract
Resident proteins of the exocytic pathway contain at least two types of information in their primary sequence for determining their subcellular location. The first type of information is found at the carboxyl terminus of soluble proteins of the endoplasmic reticulum (ER) and in the cytoplasmic domain of some ER and Golgi membrane proteins. It acts as a retrieval signal, returning proteins that have left the compartment in which they reside. The second type of information has been found in the membrane-spanning domain of several ER and Golgi proteins and, though the mechanism by which it operates is still unclear, it acts as a retention signal, keeping the protein at a particular location within the organelle. The presence of both a retrieval signal and a retention signal in a trans-Golgi network resident protein suggests that more than one mechanism operates to ensure correct localization of resident proteins along the exocytic pathway.
摘要
胞吐途径的驻留蛋白在其一级序列中至少包含两类用于确定其亚细胞定位的信息。第一类信息存在于内质网（ER）可溶性蛋白的羧基末端以及一些ER和高尔基体膜蛋白的细胞质结构域中。它作为一种回收信号，将已经离开其所在区室的蛋白回收回来。第二类信息存在于几种ER和高尔基体蛋白的跨膜结构域中，尽管其作用机制尚不清楚，但它作为一种滞留信号，将蛋白保留在细胞器内的特定位置。反式高尔基体网络驻留蛋白中同时存在回收信号和滞留信号，这表明有不止一种机制在起作用，以确保驻留蛋白在胞吐途径中正确定位。
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