Donaldson J G, Klausner R D
Cell Biology & Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892.
Curr Opin Cell Biol. 1994 Aug;6(4):527-32. doi: 10.1016/0955-0674(94)90072-8.
The small GTP-binding protein ADP ribosylation factor (ARF) regulates, through a GTP cycle, the reversible binding of cytosolic coat proteins to Golgi membranes. By determining the binding and release of coat proteins from membranes, ARF controls the production and lifetime of coated-membrane structures. In the past year, studies suggesting a role for ARF in phospholipid metabolism have broadened our perspective on ARF function within the cell.
小GTP结合蛋白ADP核糖基化因子（ARF）通过GTP循环调节胞质衣被蛋白与高尔基体膜的可逆结合。通过决定衣被蛋白与膜的结合和释放，ARF控制着被膜结构的产生和寿命。在过去的一年里，有关ARF在磷脂代谢中作用的研究拓宽了我们对细胞内ARF功能的认识。
