Fuertes Guiró F, Mortara G, Schiaffino E, d'Urbano C
Universidad de Milán, Italia.
Rev Esp Enferm Dig. 1994 Sep;86(3):694-8.
Two cases of pancreatic F-cell malignant tumors, producing only pancreatic polypeptide (PP) with clinical, biochemical and immunohistochemical features are described. No PP-associated endocrine symptoms were present. In both tumors, definitive diagnosis was immunohistochemical, and surgical treatment was carried out. Clinical evolution in the two patients was different: one of them died within the postoperative period with upper gastrointestinal bleeding by multiple duodenal ulcers, whereas the other--with lymph node metastasis at intraoperative diagnosis--is alive six years after treatment. F-cell tumors can be classified among the group of silent endocrine tumors of the pancreas. The reason for their discrepancy in the clinical behavior is unknown.
本文描述了两例胰腺F细胞恶性肿瘤，其仅产生胰多肽（PP），具有临床、生化和免疫组化特征。未出现与PP相关的内分泌症状。在这两例肿瘤中，确诊均依靠免疫组化，并实施了手术治疗。两名患者的临床病程有所不同：其中一名患者在术后因多发性十二指肠溃疡导致上消化道出血死亡，而另一名患者——术中诊断有淋巴结转移——治疗后六年仍存活。F细胞肿瘤可归类于胰腺无功能性内分泌肿瘤。其临床行为存在差异的原因尚不清楚。
