在聚肌苷酸：胞苷酸处理的小鼠中，肝磷酸烯醇丙酮酸羧激酶的激素诱导受到抑制，这是一种内毒素样糖皮质激素拮抗作用。
Inhibited hormonal induction of hepatic phosphoenolpyruvate carboxykinase in poly I: treated mice, an endotoxin-like glucocorticoid antagonism.
作者信息
Moore R N, Berry L J
出版信息
Experientia. 1976 Dec 15;32(12):1566-8. doi: 10.1007/BF01924457.
PMID:798695
Abstract
Corticosteroid induction of mouse hepatic phosphoenolpyruvate carboxykinase was inhibited by prior injection of poly I:C. Mice challenged with a lethal dose of endotoxin 4 h after administration of poly I: C could not be protected by a concurrent injection of hydrocortisone.
摘要
聚肌胞苷酸（poly I:C）预先注射可抑制皮质类固醇对小鼠肝脏磷酸烯醇丙酮酸羧激酶的诱导作用。在给予聚肌胞苷酸4小时后，用致死剂量内毒素攻击的小鼠，同时注射氢化可的松不能对其起到保护作用。
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