大鼠罕见的自发性转移性睾丸肿瘤。组织病理学和超微结构特征。

Rarely occurring spontaneous metastasizing testicular tumors in rats. Histopathologic and ultrastructural features.

作者信息

Chandra M, Riley M G

机构信息

Experimental Pathology Department, American Cyanamid Company, Pearl River, NY.

出版信息

Exp Toxicol Pathol. 1994 Jul;46(2):155-61. doi: 10.1016/S0940-2993(11)80048-5.

DOI:10.1016/S0940-2993(11)80048-5

PMID:7987074

Abstract

Testicular tumors are not uncommon in aging rats. However, metastasis from these neoplasms to several distant visceral organs has not been reported. Testicular tumors were observed in a total of 18 (1.34%) Sprague-Dawley rats out of 1340 males examined. Out of these 18 neoplasms, interstitial tumors were observed in 12 rats, of which 11 were benign and one malignant. Spermatic seminomas were observed in two (0.15%) cases (one benign and one malignant). Both rats with malignant testicular neoplasms were sacrified in extremis. Remaining four tumors were classified as mesotheliomas. Detailed gross, histopathologic and electron microscopic features of primary testicular neoplasms with metastases to several distant visceral organs are described and discussed.

摘要

睾丸肿瘤在老龄大鼠中并不罕见。然而，这些肿瘤转移至多个远处内脏器官的情况尚未见报道。在检查的1340只雄性Sprague-Dawley大鼠中，共观察到18只（1.34%）患有睾丸肿瘤。在这18个肿瘤中，12只大鼠为间质细胞瘤，其中11只为良性，1只为恶性。精原细胞瘤在2例（0.15%）中观察到（1例良性，1例恶性）。两只患有恶性睾丸肿瘤的大鼠在濒死状态下被处死。其余4个肿瘤被归类为间皮瘤。本文描述并讨论了原发性睾丸肿瘤转移至多个远处内脏器官的详细大体、组织病理学和电子显微镜特征。