影响埃及伊蚊对丝虫易感性的两个基因座的染色体定位。

Chromosomal mapping of two loci affecting filarial worm susceptibility in Aedes aegypti.

作者信息

Severson D W, Mori A, Zhang Y, Christensen B M

机构信息

Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706.

出版信息

Insect Mol Biol. 1994 May;3(2):67-72. doi: 10.1111/j.1365-2583.1994.tb00153.x.

DOI:10.1111/j.1365-2583.1994.tb00153.x

PMID:7987523

Abstract

Two quantitative trait loci (QTL) affecting susceptibility of the mosquito Aedes aegypti to the filarial worm parasite Brugia malayi were identified using restriction fragment length polymorphism (RFLP) markers. The first locus, fsb[1,LF178], resides within a 10 cM interval on chromosome 1 and exhibits a recessive effect with respect to susceptibility. The second locus, fsb[2,LF98], resides within a 9 cM interval on chromosome 2 and exhibits an additive effect on susceptibility. Significant epistasis was detected between these loci, although the effect of fsb[2,LF98] was dependent on the genetic background of the mosquito strains. Suggestions for a standard QTL nomenclature are included.

摘要

利用限制性片段长度多态性（RFLP）标记，鉴定出两个影响埃及伊蚊对丝虫寄生虫马来布鲁线虫易感性的数量性状基因座（QTL）。第一个基因座fsb[1,LF178]位于1号染色体上10厘摩的区间内，对易感性表现出隐性效应。第二个基因座fsb[2,LF98]位于2号染色体上9厘摩的区间内，对易感性表现出加性效应。尽管fsb[2,LF98]的效应取决于蚊虫品系的遗传背景，但在这些基因座之间检测到了显著的上位性。文中还给出了标准QTL命名法的建议。