[HLA - DQ基因与中国人群胰岛素依赖型糖尿病易感性]

[HLA-DQ gene and susceptibility of insulin dependent diabetes mellitus in Chinese population].

作者信息

Ji L N, Mao T S, Sun J H

机构信息

Department of Endocrinology and Metabolism, People's Hospital, Second School of Clinical Medicine, Beijing Medical University.

出版信息

Zhonghua Yi Xue Za Zhi. 1994 Jul;74(7):420-3, 455-6.

PMID:7987715

Abstract

Trans-racial analysis of disease association has improved mapping of MHC-linked susceptibility to insulin dependent diabetes mellitus (IDDM). In this study, the contribution of the HLA class II DQA1 and DQB1 genes was investigated. Nine DQA1 and 10 DQB1 sequence-specific oligonucleotide gene probing in 49 IDDM and 48 control subjects from Beijing showed that DQA1-A4 alleles was positively associated with the disease (RR = 11.7, Pc < 0.02) as was the Asp57 negative homozygotes of DQB1 gene (P < 0.01, RR = 5.3), and that Asp57 positive homozygote of DQB1 gene conferred protection against IDDM (P < 0.025, RR = 0.38). Compared with trans-racial study, the decrease of Asp57 negative homozygote frequence and increase of Asp57 positive homozygote frequence in Chinese population may contribute to the low incidence of IDDM.

摘要

疾病关联的跨种族分析改进了对与胰岛素依赖型糖尿病（IDDM）相关的MHC连锁易感性的定位。在本研究中，对HLA II类DQA1和DQB1基因的作用进行了调查。对来自北京的49例IDDM患者和48例对照者进行的9种DQA1和10种DQB1序列特异性寡核苷酸基因探测显示，DQA1 - A4等位基因与该病呈正相关（RR = 11.7，Pc < 0.02），DQB1基因的Asp57阴性纯合子也是如此（P < 0.01，RR = 5.3），而DQB1基因的Asp57阳性纯合子对IDDM有保护作用（P < 0.025，RR = 0.38）。与跨种族研究相比，中国人群中Asp57阴性纯合子频率的降低和Asp57阳性纯合子频率的增加可能是IDDM发病率较低的原因。