HLA II类等位基因在韩国胰岛素依赖型糖尿病患者中的作用。

Role of HLA class II alleles in Korean patients with IDDM.

作者信息

Lee H C, Ikegami H, Fujisawa T, Ogihara T, Park S W, Chung Y S, Park J O, Lee E J, Lim S K, Kim K R, Huh K B, Kim Y S, Lee D S, Kim D H

机构信息

Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.

出版信息

Diabetes Res Clin Pract. 1996 Mar;31(1-3):9-15. doi: 10.1016/0168-8227(96)01200-4.

DOI:10.1016/0168-8227(96)01200-4

PMID:8792097

Abstract

MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA10301 and DQA10501 were positively and DQA10102 and DQA10201 negatively associated with IDDM. DQB10301 and DQB10601 were negatively associated with IDDM. Heterodimers DQA10301-DQB10201, DQA10501-DQB10201 and DQA10501-DQB10302 were positively associated with DQA10102-DQB10601 negatively associated with IDDM. The frequencies of DR3-DQA10301-DQB10201 and -DQA10501-DQB10201 were significantly higher in diabetic patients. The frequencies of DR4-DQA10301-DQB10201 and DR9-DQA10301-DQB10303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQ beta-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.

摘要

为了研究韩国人群中MHC与胰岛素依赖型糖尿病（IDDM）的关联，以调查该疾病的遗传易感性。糖尿病患者中HLA - DR3、- DR4和 - DR9的频率显著更高。然而，糖尿病患者中DR2的频率显著降低。DQA10301和DQA10501与IDDM呈正相关，而DQA10102和DQA10201与IDDM呈负相关。DQB10301和DQB10601与IDDM呈负相关。异二聚体DQA10301 - DQB10201、DQA10501 - DQB10201和DQA10501 - DQB10302与IDDM呈正相关，DQA10102 - DQB10601与IDDM呈负相关。糖尿病患者中DR3 - DQA10301 - DQB10201和 - DQA10501 - DQB10201的频率显著更高。糖尿病患者中DR4 - DQA10301 - DQB10201和DR9 - DQA10301 - DQB10303的频率显著更高。DQβ链第57位非天冬氨酸的存在与IDDM易感性无关。然而，糖尿病患者中精氨酸52纯合子的频率显著更高。这些结果表明MHC分子的作用，也表明即使在亚洲人群中，IDDM易感性也存在种族差异。