Speaks S L, Sanger W G, Masih A S, Harrington D S, Hess M, Armitage J O
Department of Pathology/Microbiology, University of Nebraska Medical Center, Omaha 68198.
Genes Chromosomes Cancer. 1992 Oct;5(3):239-43. doi: 10.1002/gcc.2870050311.
Many nonrandom chromosome abnormalities have been associated with non-Hodgkin's lymphomas (NHL). Some of these are nonspecific changes seen in many different histologic subtypes. We describe a series of abnormalities of chromosome bands 10q23-25 seen in 159 consecutive NHL patients with abnormal cytogenetic findings. The proportion of karyotypes with abnormalities of 10q varied from 3% among the immunoblastic lymphomas to 67% in the diffuse large cleaved cell lymphomas. Seventeen (10.7%) had abnormalities of 10q23-25. All but one of these were B-cell tumors. The abnormalities consisted of six deletions and 11 translocations. Sixteen of the 17 patients had the 10q abnormality when cells were first karyotyped. The remaining patient acquired the 10q abnormality in the third of a series of biopsies. In the follicular histologic subtypes [follicular small cleaved cell (FSC), follicular mixed small cleaved and large cell (FM), and follicular large cell noncleaved (FL-NC)], abnormalities of 10q were found in nine patients, all in association with abnormalities of 14q32. Seven of these were associated with the t(14;18)(q32;q21). Overall, 10q23-25 abnormalities were observed in 11.9% (8/67) of low-grade [small lymphocytic (SL), FSC, and FM] lymphoma cases. DNA was available from five patients with abnormalities of 10q and was probed for rearrangements with the HOXII (TCL3) oncogene probe. As expected, we did not find such rearrangements in these five patients with B-cell tumors. Abnormalities of 10q23-25 have been reported previously in NHL but not at this frequency.
许多非随机染色体异常与非霍奇金淋巴瘤（NHL）相关。其中一些是在许多不同组织学亚型中可见的非特异性变化。我们描述了在159例连续的有异常细胞遗传学发现的NHL患者中观察到的一系列10q23 - 25染色体带异常。10q异常的核型比例在免疫母细胞淋巴瘤中为3%，在弥漫性大裂细胞淋巴瘤中为67%。17例（10.7%）有10q23 - 25异常。除1例之外，其余均为B细胞肿瘤。这些异常包括6例缺失和11例易位。17例患者中有16例在首次进行核型分析时就有10q异常。其余1例患者在系列活检的第三次活检时出现10q异常。在滤泡性组织学亚型[滤泡性小裂细胞（FSC）、滤泡性混合小裂细胞和大细胞（FM）以及滤泡性大细胞无裂（FL - NC）]中，9例患者发现有10q异常，均与14q32异常相关。其中7例与t(14;18)(q32;q21)相关。总体而言，在低级别[小淋巴细胞（SL）、FSC和FM]淋巴瘤病例中，11.9%（8/67）观察到10q23 - 25异常。有5例10q异常患者的DNA可供使用，并用HOXII（TCL3）癌基因探针检测重排情况。正如预期的那样，在这5例B细胞肿瘤患者中未发现此类重排。先前曾报道过NHL中有10q23 - 25异常，但未达到此频率。
