Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma.
作者信息
Bernstein R, Zeltzer P M, Lin F, Carpenter P M
机构信息
Division of Human Genetics, College of Medicine, University of California, Irvine.
出版信息
Cancer Genet Cytogenet. 1994 Nov;78(1):82-6. doi: 10.1016/0165-4608(94)90051-5.
PMID:7987812
Abstract
Chromosome studies in a 7-week-old female infant with an intraabdominal malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +der(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appears to be a nonrandom primary cytogenetic abnormality in the congenital or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.
摘要
Zotero 插件