先天性纤维肉瘤中一致的染色体数目畸变
Consistent numerical chromosome aberrations in congenital fibrosarcoma.
作者信息
Sankary S, Dickman P S, Wiener E, Robichaux W, Swaney W P, Malone P S, Gollin S M
机构信息
Department of Human Genetics, University of Pittsburgh, Pennsylvania.
出版信息
Cancer Genet Cytogenet. 1993 Feb;65(2):152-6. doi: 10.1016/0165-4608(93)90225-b.
Cytogenetic analysis of a congenital fibrosarcoma of the volar forearm from a 2.5-month-old boy revealed a mosaic karyotype 46,XY/49,XY,+11,+17,+20. This pattern of specific trisomies provides additional support to the cytogenetic findings in five cases of congenital fibrosarcoma reported previously. Trisomy 11 appears to be characteristic of congenital fibrosarcoma with additional trisomies 8, 17, and 20 as common findings.
对一名2.5个月大男婴掌侧前臂先天性纤维肉瘤进行的细胞遗传学分析显示，其核型为嵌合体46,XY/49,XY,+11,+17,+20。这种特定三体性模式为先前报道的5例先天性纤维肉瘤的细胞遗传学发现提供了更多支持。三体11似乎是先天性纤维肉瘤的特征，额外的三体8、17和20是常见发现。
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