Cho S H, Sahin A, Hortobagyi G N, Hittelman W N, Dhingra K
Department of Breast and Gynecologic Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Cancer Res. 1994 Dec 15;54(24):6302-5.
Sialyl-Tn (STn) antigen represents an aberrant glycosylation product of cell surface mucin in adenocarcinomas. We studied its expression in 40 breast carcinomas (35 of which included in situ carcinomas) by performing immunostaining with B72.3 monoclonal antibody. STn expression was observed in 50% of cases and was equally frequent in in situ and in invasive carcinomas. Positive STn staining significantly correlated with high nuclear grade (P = 0.001), aneuploidy (P < 0.001) and high S-phase fraction (P = 0.02). No correlation was observed between STn staining and age, menopausal status, presence of invasive component, or hormone receptor positivity. STn staining may provide an objective marker of dedifferentiation of breast tumors and should be investigated further for its prognostic value in breast cancers and as a biomarker of malignant transformation of breast epithelium.
唾液酸-Tn（STn）抗原是腺癌中细胞表面黏蛋白异常糖基化的产物。我们通过用B72.3单克隆抗体进行免疫染色，研究了其在40例乳腺癌（其中35例包括原位癌）中的表达情况。在50%的病例中观察到STn表达，原位癌和浸润性癌中的表达频率相同。STn染色阳性与高核分级（P = 0.001）、非整倍体（P < 0.001）和高S期分数（P = 0.02）显著相关。未观察到STn染色与年龄、绝经状态、浸润成分的存在或激素受体阳性之间的相关性。STn染色可能为乳腺肿瘤的去分化提供一个客观标志物，应进一步研究其在乳腺癌中的预后价值以及作为乳腺上皮恶性转化的生物标志物。
