Dall'Olio F, Chiricolo M
Dipartimento di Patologia Sperimentale, Università di Bologna, Via S. Giacomo 14, 40126 Bologna, Italy.
Glycoconj J. 2001 Nov-Dec;18(11-12):841-50. doi: 10.1023/a:1022288022969.
It has long been known that cancer cells often express more heavily sialylated glycans on their surface and that this feature sometimes correlates with invasion. It is now well established that specific sialylated structures, such as the Thomsen-Friedenreich-related antigens, the sialyl Lewis antigens, the sialyl alpha2-6 lactosaminyl structure, the polysialic acid or some gangliosides, can mediate cellular interactions and are altered in cancer cells. This review summarizes the current knowledge on the cancer-associated alterations in sialyltransferase expression which are often at the basis of the deranged expression of sialylated structures.
长期以来,人们一直知道癌细胞表面通常表达更多高度唾液酸化的聚糖,而且这一特征有时与侵袭相关。现在已经明确,特定的唾液酸化结构,如与汤姆森-弗里德赖希相关的抗原、唾液酸化路易斯抗原、唾液酸化α2-6乳糖胺基结构、多唾液酸或某些神经节苷脂,可介导细胞间相互作用,并且在癌细胞中会发生改变。本综述总结了目前关于唾液酸转移酶表达中与癌症相关的改变的知识,这些改变往往是唾液酸化结构表达紊乱的基础。