[Studies on the relationship between HPV and respiratory tract tumors. I. Correlation between HPV and laryngeal carcinoma].

In this paper, alpha-32P-dCTP-labeled HPV-11 and HPV-16 DNA were used as probe, and slot and Southern blot hybridization techniques were used to detect HPV-11 and HPV-16 DNA related sequences in 37 laryngeal carcinoma tissues taken from patients in Qingdao and Beijing. Using the slot blot technique, 86% (32/37) of the cases showed positive hybridization with HPV-11 probe, while 81% (30/37) showed positive results with HPV-16. Another 81% (30/37) showed positive hybridization with HPV-11 and HPV-16 simultaneously. Using Southern blot hybridization Pst digestion, the hybridization pattern corresponded to that of HPV-16 in 46; (13/28), and none corresponded to HPV-11. The results suggest that HPV-16 may induce laryngeal carcinoma.