喉癌组织中人乳头瘤病毒16型（HPV）DNA相对序列的检测
[Detection of human papillomavirus (HPV) type 16 DNA relative sequence in the tissue of laryngeal carcinoma].
作者信息
Wang H
机构信息
Shanxi Provincial Cancer Institude, Tiyuan.
出版信息
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1991;26(3):160-1, 189.
PMID:1653582
Abstract
By using alpha 32-P-dCTP labeled Chinese Human papillomavirus type 16 DNA (CHPV 16 DNA) probe, we have adopted Southern blot method and detected HPV subtype 16 DNA (1/6) and HPV 16 DNA relative sequence (3/6) in 6 biopsy specimens of laryngeal carcinoma. The result showed a severe infection of HPV in laryngeal carcinoma. This indicates that HPV infection may play a pathogenetic role in the cancer.
摘要
通过使用α-32-P-脱氧胞苷三磷酸标记的中国人乳头瘤病毒16型DNA（CHPV 16 DNA）探针，我们采用Southern印迹法，在6例喉癌活检标本中检测到HPV 16亚型DNA（1/6）和HPV 16 DNA相关序列（3/6）。结果显示喉癌中HPV感染严重。这表明HPV感染可能在该癌症中起致病作用。
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