[Prostaglandin E2 levels in gingival crevicular fluid and its relation to the depth of periodontal pocket in patients with periodontitis].

The prostaglandin E2(PGE2) levels in gingival crevicular fluid (GCF) of 46 normal controls and 90 patients suffering from periodontitis with periodontal pocket of different depth were measured by radioimmunoassay (RIA). The results demonstrated that the PGE2 levels in GCF of the periodontal pockets in periodontitis with different depth were higher than normal controls. The PGE2 levels increased with the depth of the periodontal pocket, particularly when the depth exceed over 6 mm. This study shows that the PGE2 levels are significantly related to the severity of bone destruction in periodontitis.