Lawler-Heavner J, Cruickshanks K J, Hay W W, Gay E C, Hamman R F
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262.
Diabetes Res Clin Pract. 1994 Jul;24(3):153-9. doi: 10.1016/0168-8227(94)90110-4.
A case-control study was conducted to test the hypotheses that birth size is increased in infants who develop IDDM in childhood and that birth size differs by diagnosis age. Cases were non-Hispanic white (NHW) children randomly selected from the Colorado IDDM Registry (n = 221). Controls (n = 197) were NHW children frequency-matched to cases by age-group and gender. Self-administered questionnaires collected birth size and demographic data. There were no significant univariate differences in birth weight (cases 3303.0 g; controls, 3346.1 g; P = 0.40), birth length (cases, 50.8 cm; controls, 51.2 cm; P = 0.28), or ponderal index (cases, 2.52; controls, 2.49; P = 0.92). The case/control odds ratio (OR) controlling for gender, maternal education, and birth place was 1.0 (95% confidence interval (CI) 0.4, 2.5) for the highest category of birth weight compared to the lowest. There were no statistically significant case/control differences in ponderal index (highest to lowest category OR = 1.1; 95% CI 0.6, 2.0) or birth length (1 cm increase OR, 1.0; 95% CI 0.9, 1.2). Similarly, analysis by age-at-diagnosis groups revealed no significant differences, suggesting that birth size does not reveal prenatal diabetogenic influences.
开展了一项病例对照研究，以检验以下假设：患儿童期胰岛素依赖型糖尿病（IDDM）的婴儿出生时体型更大，且出生时体型因诊断年龄而异。病例为从科罗拉多州IDDM登记处随机选取的非西班牙裔白人（NHW）儿童（n = 221）。对照（n = 197）为按年龄组和性别与病例进行频率匹配的NHW儿童。通过自行填写的问卷收集出生时体型和人口统计学数据。出生体重（病例3303.0克；对照3346.1克；P = 0.40）、出生身长（病例50.8厘米；对照51.2厘米；P = 0.28）或 ponderal指数（病例2.52；对照2.49；P = 0.92）在单变量分析中无显著差异。与最低出生体重类别相比，在控制性别、母亲教育程度和出生地的情况下，最高出生体重类别的病例/对照比值比（OR）为1.0（95%置信区间（CI）0.4, 2.5）。ponderal指数（最高类别与最低类别相比OR = 1.1；95% CI 0.6, 2.0）或出生身长（每增加1厘米OR为1.0；95% CI 0.9, 1.2）在病例/对照之间无统计学显著差异。同样，按诊断年龄组进行的分析未发现显著差异，这表明出生时体型未显示产前致糖尿病的影响。
