Hayase N, Chiba K, Abiko Y, Ichihara K
Department of Hospital Pharmacy, Asahikawa Medical College, Japan.
Eur J Pharmacol. 1994 Aug 1;260(2-3):183-90. doi: 10.1016/0014-2999(94)90336-0.
The effects of tilisolol on ischemic myocardial energy and carbohydrate metabolism were examined, and compared with those of propranolol. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min in anesthetized open-chest dogs, 5 min after saline, tilisolol (0.2 mg.kg-1, i.v.), or propranolol (1 mg.kg-1, i.v.) injection. During ischemia, the myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered, associated with ST segment elevation and TQ segment depression of the epicardial electrocardiogram. Tilisolol prevented the myocardial energy depletion and alterations of carbohydrate metabolism caused by 3 min of ischemia, to the same extent as did propranolol. Even 30 min after ischemia, the prevention of these ischemic changes was sustained by tilisolol, but not by propranolol. Tilisolol briefly reduced the ST segment elevation and TQ segment depression induced by ischemia. These results suggest that the protective effects of tilisolol on the ischemic myocardium are more potent and long-lasting than those of propranolol.
研究了替利洛尔对缺血心肌能量和碳水化合物代谢的影响，并与普萘洛尔进行了比较。在麻醉开胸犬中，通过结扎左冠状动脉前降支3或30分钟诱导缺血，在注射生理盐水、替利洛尔（0.2mg·kg-1，静脉注射）或普萘洛尔（1mg·kg-1，静脉注射）5分钟后进行。缺血期间，心肌能量储备耗竭，糖酵解中间产物水平改变，伴有心外膜心电图ST段抬高和TQ段压低。替利洛尔对3分钟缺血所致的心肌能量耗竭和碳水化合物代谢改变的预防作用与普萘洛尔相同。即使在缺血30分钟后，替利洛尔仍能持续预防这些缺血性变化，而普萘洛尔则不能。替利洛尔可短暂减轻缺血诱导的ST段抬高和TQ段压低。这些结果表明，替利洛尔对缺血心肌的保护作用比普萘洛尔更强且更持久。
