Hayase N, Chiba K, Ichihara K
Department of Hospital Pharmacy, Asahikawa Medical College, Japan.
J Pharm Sci. 1993 Mar;82(3):291-5. doi: 10.1002/jps.2600820315.
The effect of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on changes in myocardial energy and carbohydrate metabolism during ischemia was studied. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min during open-chest surgery in anesthetized dogs. The myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered by 3 and 30 min of ischemia, indicating that anaerobic myocardial metabolism had occurred. Amosulalol (0.3 or 1 mg.kg-1) was injected intravenously 5 min before ischemia. Pretreatment with amosulalol, particularly at a dose of 0.3 mg.kg-1, reduced the myocardial energy depletion and the alteration of carbohydrate metabolism induced by ischemia. This result indicates that amosulalol can reduce ischemic influences on the myocardium.
研究了α1和β肾上腺素能受体联合阻断剂阿唑洛尔对缺血期间心肌能量和碳水化合物代谢变化的影响。在麻醉犬开胸手术期间，通过结扎左冠状动脉前降支3或30分钟诱导缺血。缺血3分钟和30分钟时，心肌能量储备减少，糖酵解中间产物水平改变，表明发生了无氧心肌代谢。在缺血前5分钟静脉注射阿唑洛尔（0.3或1mg·kg-1）。阿唑洛尔预处理，特别是剂量为0.3mg·kg-1时，可减少缺血诱导的心肌能量消耗和碳水化合物代谢改变。这一结果表明，阿唑洛尔可减轻缺血对心肌的影响。
