Aznar J, Estellés A
Department of Clinical Pathology and Research Centre, La Fe University Hospital, Valencia, Spain.
Haemostasis. 1994 Jul-Aug;24(4):243-51. doi: 10.1159/000217108.
Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 (PAI-1). These levels can constitute an independent thrombotic risk factor. In addition, PAI-1 synthesis is greater in the atherosclerotic vessels than in the normal vessels and this can also constitute an atherogenic risk factor. There is a good correlation between insulinaemia and PAI-1, but it has not been demonstrated that the circulating level of PAI-1 depends exclusively on insulinaemia. The increased levels of PAI-1 correlate with other coronary risk factors, especially hypertriglyceridaemia, but high PAI-1 levels are also found in normolipaemic patients. Vascular synthesis of PAI-1 can be promoted by high levels of circulating lipoprotein a. Finally, an exercise programme can increase the fibrinolytic activity of heart disease patients towards normal.
缺血性心脏病患者的纤溶酶原激活物抑制剂1（PAI-1）水平较高。这些水平可构成独立的血栓形成危险因素。此外，PAI-1在动脉粥样硬化血管中的合成比在正常血管中更多，这也可构成动脉粥样硬化危险因素。胰岛素血症与PAI-1之间存在良好的相关性，但尚未证明PAI-1的循环水平仅取决于胰岛素血症。PAI-1水平升高与其他冠状动脉危险因素相关，尤其是高甘油三酯血症，但在血脂正常的患者中也发现PAI-1水平较高。循环中高水平的脂蛋白a可促进血管PAI-1的合成。最后，一项运动计划可使心脏病患者的纤溶活性恢复正常。
