用于评估精神分裂症临床干预措施的易感性-应激框架。

A vulnerability-stress framework for evaluating clinical interventions in schizophrenia.

作者信息

O'Connor F W

机构信息

Department of Psychosocial Nursing, University of Washington, Seattle 98195.

出版信息

Image J Nurs Sch. 1994 Fall;26(3):231-7. doi: 10.1111/j.1547-5069.1994.tb00320.x.

DOI:10.1111/j.1547-5069.1994.tb00320.x

PMID:7989069

Abstract

Symptom management and prevention of psychotic relapse are major treatment concerns in schizophrenia. Research shows a relationship between psychotic symptom levels and several intrapersonal, interpersonal, and environmental factors. These determinants are incorporated into an etiologic causal model of psychotic symptoms based on a vulnerability-stress framework. Then a multifaceted intervention model to influence symptom determinants is advanced, and examples of intervention elements are specified. Finally, a research agenda to evaluate the effectiveness of the intervention model is described, and related methodologic issues are considered.

摘要

症状管理和预防精神病复发是精神分裂症治疗中的主要关注点。研究表明，精神病症状水平与多种个人、人际和环境因素之间存在关联。基于易感性-应激框架，这些决定因素被纳入精神病症状的病因因果模型。接着提出了一个影响症状决定因素的多方面干预模型，并明确了干预要素的示例。最后，描述了一个评估干预模型有效性的研究议程，并考虑了相关的方法学问题。