Kandiloros D C, Nikolopoulos T P, Ferekidis E A, Kaloterakis A N, Papadimitriou C P, Adamopoulos G K
Department of Otolaryngology, Athens University School of Medicine, Greece.
J Laryngol Otol. 1994 Oct;108(10):868-70. doi: 10.1017/s002221510012835x.
Primary extramedullary plasmacytoma (PEP) is an uncommon neoplasm of plasma cell origin which afflicts the head and neck mainly. In this study we report a rare case of a 34-year-old man who presented with left ear tinnitus, hearing loss, blocked feeling and headache. Exploratory tympanotomy revealed a mass extending into the attic and the mastoid antrum. Following canal wall-up mastoidectomy, the tumour was carefully removed. Histological examination (including immunoperoxidase staining) and thorough clinical, laboratory and radiological evaluation revealed an exclusively cytoplasmic monoclonal IgG immunoglobulin PEP. The combination of surgery (including a second-look procedure) and radiotherapy used in this case may be an over-treatment. However, the patient is still disease-free seven years after his first admission to hospital.
原发性髓外浆细胞瘤（PEP）是一种罕见的浆细胞起源的肿瘤，主要累及头颈部。在本研究中，我们报告了一例罕见病例，一名34岁男性，表现为左耳耳鸣、听力丧失、堵塞感和头痛。 exploratory tympanotomy显示肿物延伸至鼓室上隐窝和乳突窦。行开放式乳突根治术，小心切除肿瘤。组织学检查（包括免疫过氧化物酶染色）以及全面的临床、实验室和影像学评估显示为单纯胞质型单克隆IgG免疫球蛋白PEP。本病例中使用的手术（包括二次探查手术）和放疗的联合治疗可能过度治疗了。然而，该患者首次入院后7年仍无疾病复发。
