Fioroni L, Fava M, Genazzani A D, Facchinetti F, Genazzani A R
Department of Obstetrics and Gynecology, University of Modena School of Medicine, Italy.
J Psychosom Res. 1994 Aug;38(6):617-22. doi: 10.1016/0022-3999(94)90059-0.
To evaluate the relationship between stressful life events and the onset of secondary amenorrhoea Paykel's semi-structured interview for Recent Life Events was administered to patients affected by secondary amenorrhea and also to healthy volunteers. The number, quality, and objective negative impact of life events were compared among different hormonal subtypes of secondary amenorrhoea and healthy normally menstruating women, as a control group. The number of life events in amenorrhoeic patients (N = 131) was significantly greater than those observed in the control group (N = 64) (45.9 vs 32.8%). Moreover, where only hypothalamic hypogonadotrophic amenorrhoea was considered, the occurrence of life events was significantly higher (59.8%) than in hyperandrogenic (26.6%) or in normogonadotrophic (20.4%) patients. The most prevalent events among hypothalamic hypogonadotrophic amenorrhoeic patients were those classified as 'undesirable', 'uncontrolled' and with 'Objective Negative Impact'. The present study supports the hypothesis of a cause-effect relationship between stressful personal life events and the onset of secondary amenorrhoea of hypogonadotrophic subtype.
为评估应激性生活事件与继发性闭经发病之间的关系，对继发性闭经患者及健康志愿者进行了佩克尔近期生活事件半结构化访谈。作为对照组，比较了继发性闭经不同激素亚型患者与月经正常的健康女性生活事件的数量、性质及客观负面影响。闭经患者（N = 131）的生活事件数量显著多于对照组（N = 64）（45.9% 对32.8%）。此外，仅考虑下丘脑性低促性腺激素性闭经时，生活事件的发生率显著高于高雄激素性（26.6%）或正常促性腺激素性（20.4%）患者。下丘脑性低促性腺激素性闭经患者中最常见的事件是那些被归类为“不良”“无法控制”且具有“客观负面影响”的事件。本研究支持应激性个人生活事件与低促性腺激素性亚型继发性闭经发病之间存在因果关系的假说。
