Kalashnikova L A, Nasonov E L, Baranov A A, Aleksandrova E N
Klin Med (Mosk). 1994;72(3):29-32.
An enzyme immunoassay examination of Willebrand factor antigen (WFA) was conducted in 36 patients with Sneddon's syndrome. The syndrome in 25 females and 11 males (mean age 40 years) was mainly characterized by ischemic cerebrovascular disorders in combination with advanced skin livedo. All the patients were not in an acute stroke phase. Increased WFA (above 2 IU/ml) occurred in 12 (33%) patients. Clinical manifestations, the condition severity, incidence of phospholipid antibodies, CIC levels in them were similar to those in patients with normal WFA values. The thrombotic trend in Sneddon's syndrome may result in some cases from structural endothelial damage responsible for WFA levels elevation, while under normal WFA content endothelial cell function may be affected.
对36例Sneddon综合征患者进行了血管性血友病因子抗原（WFA）的酶免疫测定。该综合征患者共25例女性和11例男性（平均年龄40岁），主要特征为缺血性脑血管疾病合并晚期皮肤网状青斑。所有患者均未处于急性卒中阶段。12例（33%）患者出现WFA升高（高于2 IU/ml）。其临床表现、病情严重程度、磷脂抗体发生率、CIC水平与WFA值正常的患者相似。Sneddon综合征的血栓形成倾向在某些情况下可能是由导致WFA水平升高的结构性内皮损伤引起的，而在WFA含量正常的情况下，内皮细胞功能可能受到影响。
