Gutierrez F, Moreno P M, Sainz M
Hospital Universitario, Departamento de Bioquimica y Biologia Molecular, Granada, Spain.
Laryngoscope. 1994 Dec;104(12):1495-8. doi: 10.1288/00005537-199412000-00012.
Recently there has been considerable investigation into the relationship of the immune system and immune disorder to Meniere's disease. Immunoglobulin G (IgG) antibody and complement are both present in endolymphatic fluid and it is possible that endolymphatic hydrops is due to immune complex. The authors' results show that patients with endolymphatic hydrops had elevated levels of circulating immune complex (CIC) of IgG (24.80 micrograms/mL). The levels of functional complement activity (CH50) were significantly lower in patients (249.7 HU) than in controls. Circulating levels of CIC and CH50 were positively correlated. Immunoglobulin G, immunoglobulin M (IgM), and subpopulation of B lymphocytes were elevated, but there was no alteration in subpopulations of T-helper, T-suppressor, and natural killer (NK) cells in peripheral blood.
最近，针对免疫系统及免疫紊乱与梅尼埃病之间的关系进行了大量研究。免疫球蛋白G（IgG）抗体和补体均存在于内淋巴液中，内淋巴积水可能是由免疫复合物引起的。作者的研究结果表明，内淋巴积水患者的循环免疫复合物（CIC）中IgG水平升高（24.80微克/毫升）。患者的功能性补体活性（CH50）水平（249.7HU）显著低于对照组。CIC和CH50的循环水平呈正相关。免疫球蛋白G、免疫球蛋白M（IgM）和B淋巴细胞亚群升高，但外周血中辅助性T细胞、抑制性T细胞和自然杀伤（NK）细胞亚群无变化。
