[Structure of aminoacyl-tRNA-synthetase of higher eukaryotes from molecular cloning data].

This review summarizes the data on the primary structure of eukaryotic aminoacyl-tRNA synthetases (EC 6.1.1) obtained during last decade by means of molecular cloning of respective cDNAs. This structural information is compared with that available for bacterial species. The alignment of E. coli, yeast and mammalian sequences are presented. The N- and C-terminal extensions of higher-eukaryotic aminoacyl-tRNA synthetases are discussed in view of their chimeric origin and potential functions. For some enzymes, the exon/intron organization of their genes are compared. A possible relationship between the domain structure of the protein and the exon/intron organization of the gene is considered.