Grigor'eva A Iu
Mol Biol (Mosk). 1994 Sep-Oct;28(5):978-90.
This review summarizes the data on the primary structure of eukaryotic aminoacyl-tRNA synthetases (EC 6.1.1) obtained during last decade by means of molecular cloning of respective cDNAs. This structural information is compared with that available for bacterial species. The alignment of E. coli, yeast and mammalian sequences are presented. The N- and C-terminal extensions of higher-eukaryotic aminoacyl-tRNA synthetases are discussed in view of their chimeric origin and potential functions. For some enzymes, the exon/intron organization of their genes are compared. A possible relationship between the domain structure of the protein and the exon/intron organization of the gene is considered.
本综述总结了过去十年间通过相应cDNA分子克隆获得的真核生物氨酰-tRNA合成酶（EC 6.1.1）一级结构的数据。将该结构信息与细菌物种的相关信息进行了比较。给出了大肠杆菌、酵母和哺乳动物序列的比对结果。鉴于高等真核生物氨酰-tRNA合成酶的嵌合起源和潜在功能，对其N端和C端延伸进行了讨论。对某些酶的基因外显子/内含子组织进行了比较。探讨了蛋白质结构域结构与基因外显子/内含子组织之间可能的关系。
