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白人女性和黑人女性中低出生体重及早产的发生率与妊娠间隔的关系。

Prevalence of low birth weight and preterm delivery in relation to the interval between pregnancies among white and black women.

作者信息

Rawlings J S, Rawlings V B, Read J A

机构信息

Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA 98431.

出版信息

N Engl J Med. 1995 Jan 12;332(2):69-74. doi: 10.1056/NEJM199501123320201.

Abstract

BACKGROUND

The higher mortality rate among black infants than among white infants in the United States results largely from the greater frequency of low birth weight and prematurity among black infants. Higher rates of low birth weight and preterm delivery have been associated with shorter intervals between pregnancies.

METHODS

We studied a racially mixed population of women in military families, who had access to free, high-quality health care. A total of 1992 white and black women had two consecutive, singleton pregnancies during the study period. We determined the outcome of the second of each pair of pregnancies and the length of time between the pregnancies.

RESULTS

Short interpregnancy intervals (calculated from delivery to the next conception) were more frequent among black than among white women. A total of 7.7 percent of the 298 black women and 3.2 percent of the 1628 white women delivered premature, low-birth-weight infants (P < 0.001). Among the black women, an interpregnancy interval of less than nine months was associated with a significantly greater prevalence of preterm delivery and low birth weight in the neonates (11.6 percent, vs. 4.4 percent for longer interpregnancy intervals; P = 0.020). Among the white women, only intervals of less than three months between pregnancies were associated with a greater prevalence of prematurity and low birth weight in the infants (11.8 percent vs. 2.8 percent; P < 0.001). Of the black women, 46.3 percent had interpregnancy intervals of less than nine months; 4.2 percent of the white women had interpregnancy intervals of less than three months.

CONCLUSIONS

A short interval between pregnancies is a risk factor for low birth weight and preterm delivery, and such intervals are more common among black than among white women. The relative frequency of intervals of less than nine months between pregnancies may be an important factor in the wide disparity in pregnancy outcomes between white and black women in the United States.

摘要

背景

在美国,黑人婴儿的死亡率高于白人婴儿,这在很大程度上是由于黑人婴儿低体重和早产的发生率更高。低体重和早产率较高与怀孕间隔时间较短有关。

方法

我们研究了军人家庭中不同种族的女性群体,她们能够获得免费的高质量医疗保健。在研究期间,共有1992名白人和黑人女性连续怀了两胎单胎妊娠。我们确定了每对妊娠中第二胎的结局以及两次妊娠之间的时间长度。

结果

黑人女性的怀孕间隔时间短(从分娩到下一次受孕计算)比白人女性更常见。在298名黑人女性中,有7.7%分娩了早产、低体重婴儿;在1628名白人女性中,这一比例为3.2%(P<0.001)。在黑人女性中,怀孕间隔时间少于9个月与新生儿早产和低体重的患病率显著更高有关(11.6%,而怀孕间隔时间较长者为4.4%;P = 0.020)。在白人女性中,只有怀孕间隔时间少于3个月与婴儿早产和低体重的患病率更高有关(11.8%对2.8%;P<0.001)。黑人女性中有46.3%的怀孕间隔时间少于9个月;白人女性中有4.2%的怀孕间隔时间少于3个月。

结论

怀孕间隔时间短是低体重和早产的一个危险因素,而且这种间隔时间在黑人女性中比在白人女性中更常见。怀孕间隔时间少于9个月的相对频率可能是美国白人和黑人女性妊娠结局存在巨大差异的一个重要因素。

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