Zitterl W, Wimberger D, Demal U, Hofer E, Lenz G
Universitätsklinik für Psychiatrie, Universität Wien.
Nervenarzt. 1994 Sep;65(9):619-22.
Eighteen patients with a DSM-III-R diagnosis of obsessive-compulsive disorder (OCD) were imaged by MR and compared to a control group of 18 patients with clinically diagnosed unspecific headaches. Weighted spin-echo sequences were carried out with a 1.5T unit in both axial and coronal planes T1 (TR 700/TE 15 ms) and T2 (TR 2500/TE 15.70). The ferritin distributions in the basal ganglia and in the midbrain were evaluated; in addition, the width of the pars compacta in the midbrain on the basis of the criteria of Braffmann et al. 1988, the widths of the inner subarachnoid spaces on the basis of the ventricular index quotient VIQ (TerBrugge, 1986), and the widths of the outer subarachnoid spaces were conducted. The latter was undertaken by three independent investigators whose results were in agreement with one another. In 12 of the OCD patients (n = 18) there was a total of 25 pathological MRI findings; in the control group there were 6 pathological MRI findings in only 6 of the patients (n = 18). In conclusion pathological changes were found at different locations, but a connection between a specific neuroanatomic system and obsessive-compulsive disorder could not be demonstrated.
对18例经《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）诊断为强迫症（OCD）的患者进行了磁共振成像（MR）检查，并与18例临床诊断为非特异性头痛的患者组成的对照组进行了比较。使用1.5T设备在轴向和冠状面进行加权自旋回波序列扫描，T1序列（重复时间[TR]700/回波时间[TE]15毫秒）和T2序列（TR 2500/TE 15.70）。评估了基底神经节和中脑的铁蛋白分布；此外，根据Braffmann等人1988年的标准测量了中脑黑质致密部的宽度，根据脑室指数商（VIQ，TerBrugge，1986）测量了蛛网膜下腔内间隙的宽度，并测量了蛛网膜下腔外间隙的宽度。后者由三名独立研究人员进行，他们的结果相互一致。在18例强迫症患者中有12例共出现25项病理磁共振成像结果；对照组中18例患者只有6例出现6项病理磁共振成像结果。总之，在不同部位发现了病理变化，但未证实特定神经解剖系统与强迫症之间存在关联。
