Arumanayagam M, Feng C S, Cockram C S, Swaminathan S R
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Pathology. 1994 Jul;26(3):291-3. doi: 10.1080/00313029400169681.
The mechanism by which erythrocyte mean corpuscular volume (MCV) is decreased in hyperthyroidism is not known. One possible mechanism is premature aging of erythrocytes in the circulation. Since erythrocyte creatine has been shown to be a good marker of cell senescence, we determined this in hyperthyroid patients and control subjects to examine whether the decrease in MCV is related to senescence. Erythrocyte creatine levels were similar in both hyperthyroid patients and controls, suggesting that premature senescence of erythrocytes does not account for the lower MCV in hyperthyroidism.
甲状腺功能亢进症时红细胞平均体积（MCV）降低的机制尚不清楚。一种可能的机制是循环中红细胞过早衰老。由于红细胞肌酸已被证明是细胞衰老的良好标志物，我们测定了甲状腺功能亢进症患者和对照者的红细胞肌酸，以检查MCV降低是否与衰老有关。甲状腺功能亢进症患者和对照组的红细胞肌酸水平相似，这表明红细胞过早衰老并不能解释甲状腺功能亢进症时MCV较低的原因。
