Weber H S, Myers J L
Section of Pediatric Cardiology, Pennsylvania State University Childrens Hospital, Hershey.
Pediatr Cardiol. 1994 Jul-Aug;15(4):204-6. doi: 10.1007/BF00800677.
We report the case of a fetus diagnosed at 24 weeks' gestation with complete heart block associated with maternal collagen vascular disease and Sjögren's antibody. Serial fetal echocardiograms noted increased echogenicity along the tricuspid and mitral valves without insufficiency. Postnatally, severe tricuspid insufficiency occurred following placement of an endocardial pacing lead, and severe mitral insufficiency occurred acutely at 2.5 months of age. Both valves were noted at surgery to have fibrotic and calcific chordae tendineae that had ruptured from their papillary muscles. An inflammatory reaction within the fetal heart related to transplacental passage of Sjögren's antibody was likely responsible.
我们报告一例妊娠24周时诊断出的胎儿，其患有与母体胶原血管疾病和干燥综合征抗体相关的完全性心脏传导阻滞。系列胎儿超声心动图显示三尖瓣和二尖瓣回声增强但无反流。出生后，放置心内膜起搏导线后出现严重三尖瓣反流，2.5月龄时急性出现严重二尖瓣反流。手术中发现两个瓣膜均有纤维化和钙化的腱索，这些腱索已从乳头肌断裂。胎儿心脏内与干燥综合征抗体经胎盘传递相关的炎症反应可能是其原因。
